| Rank | Teams | Played | Won | Drawn | Lost | Differential | Goal difference | Points |
|---|---|---|---|---|---|---|---|---|
| 1 |
 Lautaro de Buin |
22 | 14 | 5 | 3 | 36 - 18 | 18 | 47 |
| 2 |
 Fernández Vial |
22 | 14 | 3 | 5 | 37 - 19 | 18 | 45 |
| 3 |
 Deportes Recoleta |
22 | 11 | 4 | 7 | 44 - 34 | 10 | 37 |
| 4 |
 General Velásquez |
22 | 9 | 6 | 7 | 29 - 22 | 7 | 33 |
| 5 |
 Colchagua CD |
22 | 8 | 5 | 9 | 23 - 28 | -5 | 29 |
| 6 |
 Iberia |
22 | 7 | 7 | 8 | 27 - 24 | 3 | 28 |
| 7 |
 San Antonio Unido |
22 | 7 | 7 | 8 | 23 - 25 | -2 | 28 |
| 8 |
 Independiente de Cauquenes |
22 | 7 | 7 | 8 | 24 - 27 | -3 | 28 |
| 9 |
 Deportes Colina |
22 | 7 | 4 | 11 | 30 - 39 | -9 | 22 |
| 10 |
 Deportes Concepción |
22 | 5 | 6 | 11 | 23 - 30 | -7 | 21 |
| 11 |
 Deportes Vallenar |
22 | 5 | 8 | 9 | 17 - 30 | -13 | 20 |
| 12 |
 Deportes Linares |
22 | 4 | 6 | 12 | 19 - 36 | -17 | 18 |
Asciende al Campeonato PrimeraB 2021
Desciende a la Tercera División 2021
Desciende a la Tercera División 2021
