| Rank | Teams | Played | Won | Drawn | Lost | Differential | Goal difference | Points | Current form |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
 San Marcos de Arica |
22 | 13 | 4 | 5 | 33 - 15 | 18 | 43 | WDWLW |
| 2 |
 General Velásquez |
22 | 10 | 6 | 6 | 25 - 20 | 5 | 36 | DWWDD |
| 3 |
 Deportes Valdivia |
22 | 11 | 2 | 9 | 29 - 25 | 4 | 35 | WWLLL |
| 4 |
 Lautaro de Buin |
22 | 10 | 2 | 10 | 29 - 34 | -5 | 32 | WWWWL |
| 5 |
 Real San Joaquín |
22 | 9 | 3 | 10 | 28 - 37 | -9 | 30 | LWWLW |
| 6 |
 San Antonio Unido |
22 | 7 | 8 | 7 | 22 - 19 | 3 | 29 | DDDWW |
| 7 |
 Trasandino |
22 | 7 | 8 | 7 | 27 - 25 | 2 | 29 | LDLDL |
| 8 |
 Iberia |
22 | 6 | 10 | 6 | 18 - 17 | 1 | 28 | DDLWD |
| 9 |
 Deportes Limache |
22 | 7 | 8 | 7 | 26 - 28 | -2 | 28 | DWWWL |
| 10 |
 Deportes Concepción |
22 | 7 | 5 | 10 | 20 - 25 | -5 | 26 | LLLLW |
| 11 |
 Rodelindo |
22 | 5 | 9 | 8 | 27 - 25 | 2 | 24 | LDLWL |
| 12 |
 Independiente de Cauquenes |
22 | 6 | 3 | 13 | 20 - 34 | -14 | 21 | LDLLW |
Campeón y sube al Ascenso 2023
Descenso a Tercera A 2023
