| Rank | Teams | Played | Won | Drawn | Lost | Differential | Goal difference | Points | Current form |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
 San Marcos de Arica |
21 | 12 | 4 | 5 | 31 - 14 | 17 | 40 | DWDWL |
| 2 |
 Deportes Valdivia |
21 | 11 | 2 | 8 | 28 - 23 | 5 | 35 | WWWLL |
| 3 |
 General Velásquez |
21 | 10 | 5 | 6 | 25 - 20 | 5 | 35 | LDWWD |
| 4 |
 Lautaro de Buin |
21 | 10 | 2 | 9 | 29 - 32 | -3 | 32 | DWWWW |
| 5 |
 Trasandino |
21 | 7 | 8 | 6 | 26 - 23 | 3 | 29 | DLDLD |
| 6 |
 Deportes Limache |
21 | 7 | 8 | 6 | 25 - 26 | -1 | 28 | DDWWW |
| 7 |
 Iberia |
21 | 6 | 9 | 6 | 18 - 17 | 1 | 27 | DDDLW |
| 8 |
 Real San Joaquín |
21 | 8 | 3 | 10 | 26 - 36 | -10 | 27 | DLWWL |
| 9 |
 San Antonio Unido |
21 | 6 | 8 | 7 | 20 - 19 | 1 | 26 | LDDDW |
| 10 |
 Rodelindo |
21 | 5 | 9 | 7 | 26 - 23 | 3 | 24 | DLDLW |
| 11 |
 Deportes Concepción |
21 | 6 | 5 | 10 | 18 - 24 | -6 | 23 | LLLLL |
| 12 |
 Independiente de Cauquenes |
21 | 5 | 3 | 13 | 18 - 33 | -15 | 18 | WLDLL |
Campeón y sube al Ascenso 2023
Descenso a Tercera A 2023
