| Rank | Teams | Played | Won | Drawn | Lost | Differential | Goal difference | Points | Current form |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
 Deportes Recoleta |
22 | 15 | 3 | 4 | 38 - 24 | 14 | 48 | WDWWD |
| 2 |
 Iberia |
22 | 12 | 4 | 6 | 34 - 26 | 8 | 40 | WDLLW |
| 3 |
 Deportes Limache |
22 | 9 | 8 | 5 | 36 - 22 | 14 | 35 | DDLDD |
| 4 |
 Independiente de Cauquenes |
22 | 10 | 2 | 10 | 38 - 32 | 6 | 32 | LLLLD |
| 5 |
 Lautaro de Buin |
22 | 9 | 5 | 8 | 32 - 30 | 2 | 32 | WDWLL |
| 6 |
 General Velásquez |
22 | 8 | 7 | 7 | 33 - 33 | 0 | 31 | WDWDD |
| 7 |
 San Antonio Unido |
22 | 8 | 6 | 8 | 34 - 36 | -2 | 30 | WLDLW |
| 8 |
 Deportes Valdivia |
22 | 8 | 6 | 8 | 29 - 27 | 2 | 27 | DDWWD |
| 9 |
 Rodelindo Román |
22 | 7 | 6 | 9 | 23 - 34 | -11 | 27 | DLDWD |
| 10 |
 Deportes Concepción |
22 | 5 | 8 | 9 | 22 - 29 | -7 | 23 | LLWDD |
| 11 |
 Atlético Colina |
22 | 5 | 4 | 13 | 19 - 31 | -12 | 19 | LWDWL |
| 12 |
 Colchagua CD |
22 | 5 | 3 | 14 | 23 - 37 | -14 | 18 | LWDLD |
Asciende al Campeonato Ascenso 2022
Desciende a la Tercera División 2022
Desciende a la Tercera División 2022