| Rank | Teams | Played | Won | Drawn | Lost | Differential | Goal difference | Points | Current form |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
 Deportes Recoleta |
13 | 9 | 1 | 3 | 22 - 15 | 7 | 28 | WWWWD |
| 2 |
 Deportes Limache |
13 | 7 | 4 | 2 | 25 - 9 | 16 | 25 | DWLWW |
| 3 |
 Iberia |
13 | 8 | 1 | 4 | 20 - 14 | 6 | 25 | WWLWL |
| 4 |
 Independiente de Cauquenes |
13 | 7 | 1 | 5 | 23 - 17 | 6 | 22 | WWWLL |
| 5 |
 Rodelindo |
13 | 6 | 1 | 6 | 16 - 23 | -7 | 19 | WWWWW |
| 6 |
 Deportes Valdivia |
13 | 6 | 3 | 4 | 20 - 14 | 6 | 18 | WLDLW |
| 7 |
 San Antonio Unido |
13 | 5 | 3 | 5 | 19 - 21 | -2 | 18 | WLWLL |
| 8 |
 Lautaro de Buin |
13 | 4 | 4 | 5 | 13 - 15 | -2 | 16 | LWDWD |
| 9 |
 Deportes Concepción |
13 | 3 | 4 | 6 | 12 - 16 | -4 | 13 | LDDLW |
| 10 |
 General Velásquez |
13 | 3 | 4 | 6 | 12 - 17 | -5 | 13 | LLLDL |
| 11 |
 Colchagua CD |
13 | 3 | 1 | 9 | 10 - 20 | -10 | 10 | LLLDW |
| 12 |
 Deportes Colina |
13 | 2 | 3 | 8 | 7 - 18 | -11 | 9 | WLLLL |
Asciende al Campeonato Ascenso 2022
Desciende a la Tercera División 2022
Desciende a la Tercera División 2022