| Rank | Teams | Played | Won | Drawn | Lost | Differential | Goal difference | Points | Current form |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
 Iberia |
3 | 3 | 0 | 0 | 8 - 2 | 6 | 9 | WWW?? |
| 2 |
 Deportes Valdivia |
3 | 2 | 0 | 1 | 6 - 2 | 4 | 6 | WLW?? |
| 3 |
 Deportes Recoleta |
2 | 2 | 0 | 0 | 2 - 0 | 2 | 6 | WW??? |
| 4 |
 San Antonio Unido |
3 | 1 | 2 | 0 | 4 - 3 | 1 | 5 | DDW?? |
| 5 |
 General Velásquez |
3 | 1 | 1 | 1 | 3 - 2 | 1 | 4 | WDL?? |
| 6 |
 Deportes Limache |
3 | 1 | 1 | 1 | 3 - 3 | 0 | 4 | DLW?? |
| 7 |
 Independiente de Cauquenes |
3 | 1 | 0 | 2 | 4 - 5 | -1 | 3 | LWL?? |
| 8 |
 Deportes Colina |
2 | 1 | 0 | 1 | 1 - 2 | -1 | 3 | WL??? |
| 9 |
 Deportes Concepción |
3 | 0 | 1 | 2 | 4 - 7 | -3 | 1 | LDL?? |
| 10 |
 Rodelindo Román |
3 | 0 | 1 | 2 | 1 - 6 | -5 | 1 | LDL?? |
| 11 |
 Lautaro de Buin |
0 | 0 | 0 | 0 | 0 - 0 | 0 | 0 | ????? |
| 12 |
 Colchagua CD |
2 | 0 | 0 | 2 | 1 - 5 | -4 | 0 | LL??? |
Asciende al Campeonato Ascenso 2022
Desciende a la Tercera División 2022
Desciende a la Tercera División 2022